Lazar Toxicity Predictions

EPA Fathead Minnow Acute Toxicity (EPAFHM)

• 96 hr LC50

Human liver toxicity

• Composite activity
• Alkaline phosphatase increase
• GGT increase
• LDH increase
• SGOT increase
• SGPT increase

Mutagenicity

• Salmonella typhimurium (CPDB)
• Salmonella typhimurium (Kazius/Bursi)

Carcinogenicity

• Rodent carcinogenicity (multiple sex/species/sites)
• Rodent carcinogenicity (single sex/species/site)
• Rat carcinogenicity (both sexes)
• Rat carcinogenicity (male)
• Rat carcinogenicity (female)
• Mouse carcinogenicity (both sexes)
• Mouse carcinogenicity (male)
• Mouse carcinogenicity (female)
• Hamster carcinogenicity (both sexes)
• Hamster carcinogenicity (male)
• Hamster carcinogenicity (female)
• IRIS upper-bound excess lifetime cancer risk

FDA Maximum Recommended Daily Dose (FDAMDD)

• Maximum recommended daily dose